While stool samples showed only moderate increases in these genes, oral samples showed significant increases in their prevalence in samples taken from migraine sufferers. 16S rRNA sequencing confirmed that those with migraines had much higher levels of nitrate-reducing bacteria in their mouths. Further analyses indicated that the prevalence of these bacteria was driven by host physiology.
Find Out Who’s In Your Gut - The ribosome is the factory that makes proteins and is found in all cells, and fascinatingly it is mostly made of RNA. One RNA subunit, called the 16S rRNA, is especially effective as a barcode for understanding which microbes (specifically, bacteria and archaea) are found in a given sample. This PERK includes DNA extraction and 16S rRNA sequencing of one stool sample