How to clean a pack n play. MUST DO THIS! 1/2 C. Laundry detergent, 1/4 C. baking soda, 1/4 C. Vinegar in a tub of hot water. Let set for 45 minutes then flip over and add a little bit more hot water let sit for another hour. Drain the tub and rinse the mat and frame. let sit for 24 hours to completely dry.