A GIF created by the Amoeba Sisters demonstrating how a substrate binds to the active site of an enzyme. #AmoebaGIFs http://www.amoebasisters.com/amoebagifs.html
Catalysts are of paramount importance to achieve high efficiency and economic profit for most heterogeneous reactions. Since catalytic reaction occurs only when reactants reach the active sites, these active sites must be maximally exposed at the surface in a high efficiency catalyst.
Triumeq contains 3 different medicines that work together to treat your HIV-1 infection: dolutegravir, abacavir, and lamivudine. Dolutegravir binds to the integrase active site and blocks the strand transfer step of retroviral DNA integration in order to inhibit HIV integrase. Abacavir and lamivudine inhibit HIV reverse transcriptase and, by incorporating monophosphate, form a chain termination on the DNA viral chain.