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Alpha Adrenergic Agonist

Multiple System Atrophy aka Shy-Drager Disease... Parkinsonism + Autonomic Dysfunction + Neurological Signs... increased falls, dizziness, orthostatic hypotension, erectile dysfunction, resting tremor, rigidity, bradykinesia... Treated with intravascular volume expansion, fludrocortisone, salt supplements, alpha adrenergic agonists, and constrictive garments

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α2 receptors are located on the presynaptic terminal. eg Clonidine ligand is an α2 receptor agonist.

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β1 (eg metoprolol is a β1 blocker) & β2 (eg albuterol is a β2 agonist) receptors work by Gs (AC -> cAMP -> PKA), while α1 (eg terazosin is an α1 blocker) work by Gq (PLC -> PIP2, IP3 -> Ca2+, DAG -> PKC. Besides the heart, β1 receptors are used for aqueous humor production.

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