"American Dad!" is an American adult animated sitcom created by Seth MacFarlane, Mike Barker, and Matt Weitzman for the Fox Broadcasting Company. American Dad! is the first television series to have its inception on Animation Domination. The series premiere aired on February 6, 2005.
AMERICAN DAD... I want to say that my favorite comedic animated series is The Simpsons. But I don't really watch it often (I want to start with season 1, and will eventually). So this is top dog in my book.