Why Does Alemtuzumab cause B cell autoimmunity? The perfect Storm   Baker D Herrod SS Alvarez-Gonzalez C Giovannoni G Schmierer K.Interpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab. JAMA Neurol. 2017 Jun 12. doi: 10.1001/jamaneurol.2017.0676. [Epub ahead of print] IMPORTANCE:Alemtuzumab a CD52-depleting monoclonal antibody effectively inhibits relapsing multiple sclerosis (MS) but is associated with a high incidence of secondary B-cell autoimmunities…

Why Does Alemtuzumab cause B cell autoimmunity? The perfect Storm Baker D Herrod SS Alvarez-Gonzalez C Giovannoni G Schmierer K.Interpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab. JAMA Neurol. 2017 Jun 12. doi: 10.1001/jamaneurol.2017.0676. [Epub ahead of print] IMPORTANCE:Alemtuzumab a CD52-depleting monoclonal antibody effectively inhibits relapsing multiple sclerosis (MS) but is associated with a high incidence of secondary B-cell autoimmunities…

B cell dependent EAE   Sefia E Pryce G Meier UC Giovannoni G Baker D. Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis. Mult Scler Relat Disord. 2017 May;14:46-50. doi: 10.1016/j.msard.2017.03.013.  This paper warns about the value of using mice to understand B cell activity in MS. It looks at a few published studies or mouse studies and asks you to think.  If we look in the abstract in the paper below  the work is now done in a B cell- and…

B cell dependent EAE Sefia E Pryce G Meier UC Giovannoni G Baker D. Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis. Mult Scler Relat Disord. 2017 May;14:46-50. doi: 10.1016/j.msard.2017.03.013. This paper warns about the value of using mice to understand B cell activity in MS. It looks at a few published studies or mouse studies and asks you to think. If we look in the abstract in the paper below the work is now done in a B cell- and…

Alemtuzumab kills B cells. Not Really a Stepford Wife   So we talked about our new paper that came out yesterday.David Baker; Samuel S. Herrod Cesar Alvarez-Gonzalez Gavin Giovannoni; Klaus SchmiererInterpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab.JAMA Neurol. Published online June 12 2017. doi:10.1001/jamaneurol.2017.0676  IMPORTANCE Alemtuzumab a CD52-depleting monoclonal antibody effectively inhibits relapsing multiple sclerosis (MS) but is…

Alemtuzumab kills B cells. Not Really a Stepford Wife So we talked about our new paper that came out yesterday.David Baker; Samuel S. Herrod Cesar Alvarez-Gonzalez Gavin Giovannoni; Klaus SchmiererInterpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab.JAMA Neurol. Published online June 12 2017. doi:10.1001/jamaneurol.2017.0676 IMPORTANCE Alemtuzumab a CD52-depleting monoclonal antibody effectively inhibits relapsing multiple sclerosis (MS) but is…

Differences Between B-Cells and T-Cells. T cells and B cells are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity.

Differences Between B-Cells and T-Cells. T cells and B cells are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity.

A DYI look at shipping container home insulation and how to go about choosing material for insulating a container home #containerhome #shippingcontainer

A DYI look at shipping container home insulation and how to go about choosing material for insulating a container home #containerhome #shippingcontainer

How does Cladribine Work. It kills B cells   David BakerSamuel S. HerrodCesar Alvarez-GonzalezLukasz ZalewskiChristo Albor and Klaus Schmierer. Both cladribine and alemtuzumab may effect MS via B-cell depletion  Neurology Neuroimmunology Neurosurgery. http://dx.doi.org/10.1212/NXI.0000000000000360Objective: To understand the efficacy of cladribine (CLAD) treatment in MS through analysis of lymphocyte subsets collected but not reported in the pivotal phase III trials of cladribine and…

How does Cladribine Work. It kills B cells David BakerSamuel S. HerrodCesar Alvarez-GonzalezLukasz ZalewskiChristo Albor and Klaus Schmierer. Both cladribine and alemtuzumab may effect MS via B-cell depletion Neurology Neuroimmunology Neurosurgery. http://dx.doi.org/10.1212/NXI.0000000000000360Objective: To understand the efficacy of cladribine (CLAD) treatment in MS through analysis of lymphocyte subsets collected but not reported in the pivotal phase III trials of cladribine and…

B cells as antigen presenting cells.   Fraussen J Claes N Van Wijmeersch B van Horssen J Stinissen P Hupperts R Somers V. B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses. Clin Immunol. 2016 . pii: S1521-6616(16)30163-2 Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study B cell antigen presentation and costimulation in MS were studied. Peripheral blood B cells of MS patients showed…

B cells as antigen presenting cells. Fraussen J Claes N Van Wijmeersch B van Horssen J Stinissen P Hupperts R Somers V. B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses. Clin Immunol. 2016 . pii: S1521-6616(16)30163-2 Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study B cell antigen presentation and costimulation in MS were studied. Peripheral blood B cells of MS patients showed…

"Say What: Statement iPhone Cases" by polyvore-editorial ❤ liked on Polyvore featuring iPhonecases, accessories, tech accessories, phone cases, phone, cases, electronics, iphone case, iphone cover case and apple iphone cases

"Say What: Statement iPhone Cases" by polyvore-editorial ❤ liked on Polyvore featuring iPhonecases, accessories, tech accessories, phone cases, phone, cases, electronics, iphone case, iphone cover case and apple iphone cases

The pain of the peer-review process   It is interesting but if you ask Pharma what they think is interesting these days. They say B cells. However try publish this idea and you run into the academic T cell brigade. They like me have made their careers on T cell research and they are going to look for as many holes in your B cell ideas as possible. We were surprised the manuscript was not rejected one referee wanted us to do more work which was impossible to do. We addressed the comments as…

The pain of the peer-review process It is interesting but if you ask Pharma what they think is interesting these days. They say B cells. However try publish this idea and you run into the academic T cell brigade. They like me have made their careers on T cell research and they are going to look for as many holes in your B cell ideas as possible. We were surprised the manuscript was not rejected one referee wanted us to do more work which was impossible to do. We addressed the comments as…

Cool DIY Ideas for Your iPhone iPad Tablets & Phones | Fun Projects for Chargers, Cases and Headphones | Popsicle Pattern iPhone Covers | http://diyprojectsforteens.com/diy-projects-iphone-ipad-phone/

Awesome DIYs for your Tech Toys

Cool DIY Ideas for Your iPhone iPad Tablets & Phones | Fun Projects for Chargers, Cases and Headphones | Popsicle Pattern iPhone Covers | http://diyprojectsforteens.com/diy-projects-iphone-ipad-phone/

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