The Battle of Issus occurred in southern Anatolia, in November 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Persia, led by Darius III, in the second great battle of Alexander's conquest of Asia. The invading Macedonian troops defeated Persia-Alexander battling Darius at the Battle of Issus (Naples National Archaeological Museum)
333 BC - Alexander the Great defeats Persia under Darius at battle of Issus. Alexander was the fourth in a line of great men and scholars: Socrates, Plato, Aristotle. Darius escapes and gathers his forces for the next battle.