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A BRAF gene mutation in melanoma patients has been found to respond to MEK inhibitor drugs, providing a reason for routine screening and therapy in melanoma patients with the BRAF L597 mutation.

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BRAF: From Gene to Cancer Therapy

Look at real cancer DNA datasets (from cancer patients) to find areas of mutation in the BRAF gene [yourgenome.org]

Drug-Resistant Melanoma Treatment May Be Enhanced: Study - More than 8,000 Americans are killed each year by melanoma — the deadliest form of skin cancer. The presence of mutations in a gene known as the BRAF gene drives approximately 40 percent of advanced melanoma tumors. | RedOrbit/Nov 2013

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Colorectal carcinoma is the most frequent type of bowel cancer and the second most common tumour disease among men and women in Germany. So-called microsatellite stable colorectal cancer with mutations in the BRAF gene represents a particularly aggressive form. The BRAF gene produces the enzyme B-Raf, ...

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BRAF Gene Mutations Are Rare Events in Gastroenteropancreatic Neuroendocrine Tumors - Click on Image

About half of all advanced melanomas have a defect in the BRAF gene. A new strategy may extend the survival time of people living with the most serious form of skin cancer.

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Targeted Tx Slows Melanoma Progress

A new drug that targets mutated BRAF in metastatic #melanoma showed greater progression-free survival (PFS) compared with conventional chemotherapy, an open-label phase III trial found.

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Single driver mutation found in papillary #craniopharyngioma , the adult form of the tumor. A research team at the Broad Institute & Dana-Farber has uncovered a single mutation in the gene BRAF was found in nearly all tumor cells in nearly all cases studied..The scenario suggests it is a potent therapeutic target...(read inside) (via Broad Institute, posted Jan 30, 2014). Also here: http://www.dddmag.com/news/2014/01/targetable-mutation-found-rare-brain-tumor

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