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A BRAF gene mutation in melanoma patients has been found to respond to MEK inhibitor drugs, providing a reason for routine screening and therapy in melanoma patients with the BRAF L597 mutation.

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from yourgenome

BRAF: From Gene to Cancer Therapy

Look at real cancer DNA datasets (from cancer patients) to find areas of mutation in the BRAF gene [yourgenome.org]

Drug-Resistant Melanoma Treatment May Be Enhanced: Study - More than 8,000 Americans are killed each year by melanoma — the deadliest form of skin cancer. The presence of mutations in a gene known as the BRAF gene drives approximately 40 percent of advanced melanoma tumors. | RedOrbit/Nov 2013

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Colorectal carcinoma is the most frequent type of bowel cancer and the second most common tumour disease among men and women in Germany. So-called microsatellite stable colorectal cancer with mutations in the BRAF gene represents a particularly aggressive form. The BRAF gene produces the enzyme B-Raf, ...

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There are two different subtypes of #Craniopharyngioma (CP): papillary (papCP) and adamantinomatous (adaCP) which harbor distinctive gene mutations. BRAF V600E mutations were solely found in the papCP subgroup and were not detectable in adaCP samples. In contrast, CTNNB1 mutations were exclusively detected in adaCP. (Read full article (open access) inside, published Feb 2016)

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About half of all advanced melanomas have a defect in the BRAF gene. A new strategy may extend the survival time of people living with the most serious form of skin cancer.

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Single driver mutation found in papillary #craniopharyngioma , the adult form of the tumor. A research team at the Broad Institute & Dana-Farber has uncovered a single mutation in the gene BRAF was found in nearly all tumor cells in nearly all cases studied..The scenario suggests it is a potent therapeutic target...(read inside) (via Broad Institute, posted Jan 30, 2014). Also here: http://www.dddmag.com/news/2014/01/targetable-mutation-found-rare-brain-tumor

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