The Flintstones is the best family-friendly cartoon. It is about a family of cavemen living in a society very similar to 20th century America. It was way better than the Jetsons. It was inspired by the Honeymooners and served as inspiration for cartoons like the Simpsons and Family Guy.
Dick Dastardly and Muttley - I've never been a big fan of anything Hannah Barbera, but you have to give it up for these guys. Two of the best voices in cartoon history and their chemistry was pretty good too!