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The chromosomal translocation characteristic of 70 percent of MCL(Mantel Cell Lymphoma) cases occurs between chromosomes 11 and 14 resulting in the overexpression of cyclinD1

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X-Chromosomal Translocation and Segmental Hypopigmentation — NEJM hypomelanosis of Ito

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In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes

Chromosomal translocation & associated neoplasms...

Ewing/PNET characteristic t(11;22) (q24;q12) leading to EWS-FLI1 fusion is encountered in 85% of Ewing Sarcoma/PNET cases. The majority of remaining cases (10-15%) demonstrate fusion of the EWS gene with a second member of the ETS family of genes, namely ERG. The EWS-ERG fusion occurs as a result of chromosomal translocation t(21;22)(q22;q12)

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BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine le...

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Janet Rowley - Discover of chromosomal translocations leading to disease. Did this at the University of Chicago while working part time and raising her family. Awarded Presidential Medal of Freedom by Barak Obama