X-Chromosomal Translocation and Segmental Hypopigmentation — NEJM  hypomelanosis of Ito

X-Chromosomal Translocation and Segmental Hypopigmentation — NEJM hypomelanosis of Ito

Chromosomal translocation & associated neoplasms...

Chromosomal translocation & associated neoplasms...

Mll #mll http://money.nef2.com/mll-mll/  # This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed…

Mll #mll http://money.nef2.com/mll-mll/ # This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed…

Ewing/PNET characteristic t(11;22) (q24;q12) leading to EWS-FLI1 fusion is encountered in 85% of Ewing Sarcoma/PNET cases. The majority of remaining cases (10-15%) demonstrate fusion of the EWS gene with a second member of the ETS family of genes, namely ERG. The EWS-ERG fusion occurs as a result of chromosomal translocation t(21;22)(q22;q12)

Ewing/PNET characteristic t(11;22) (q24;q12) leading to EWS-FLI1 fusion is encountered in 85% of Ewing Sarcoma/PNET cases. The majority of remaining cases (10-15%) demonstrate fusion of the EWS gene with a second member of the ETS family of genes, namely ERG. The EWS-ERG fusion occurs as a result of chromosomal translocation t(21;22)(q22;q12)

BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine le...

BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine le...

The chromosomal translocation characteristic of 70 percent of MCL(Mantel Cell Lymphoma) cases occurs between chromosomes 11 and 14 resulting in the overexpression of cyclinD1

The chromosomal translocation characteristic of 70 percent of MCL(Mantel Cell Lymphoma) cases occurs between chromosomes 11 and 14 resulting in the overexpression of cyclinD1

Chromosomal translocation...

Chromosomal translocation...

Scientists decipher the molecular basis of an as yet incurable leukemia in children - Although intensive research over the least decade has led to significant improvement of the survival rates of children suffering from ALL, a subset of patients still remains resistant to treatment. One such example is a very aggressive and incurable subtype associated with a t(17;19) chromosomal translocation, which occurs due to breakage and aberrant fusion of genetic material in the tumour cells…

Scientists decipher the molecular basis of an as yet incurable leukemia in children - Although intensive research over the least decade has led to significant improvement of the survival rates of children suffering from ALL, a subset of patients still remains resistant to treatment. One such example is a very aggressive and incurable subtype associated with a t(17;19) chromosomal translocation, which occurs due to breakage and aberrant fusion of genetic material in the tumour cells…

Image result for chromosomal translocation

Image result for chromosomal translocation

Janet Rowley - Discover of chromosomal translocations leading to disease.  Did this at the University of Chicago while working part time and raising her family.  Awarded Presidential Medal of Freedom by Barak Obama

Janet Rowley - Discover of chromosomal translocations leading to disease. Did this at the University of Chicago while working part time and raising her family. Awarded Presidential Medal of Freedom by Barak Obama

Images in Clinical Medicine from The New England Journal of Medicine — X-Chromosomal Translocation and Segmental Hypopigmentation

Images in Clinical Medicine from The New England Journal of Medicine — X-Chromosomal Translocation and Segmental Hypopigmentation

In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes

In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes

#NIH scientists visualize how #cancer chromosome abnormalities form in living cells. (Image: A chromosome translocation visualized in 3D) irp.nih.gov

#NIH scientists visualize how #cancer chromosome abnormalities form in living cells. (Image: A chromosome translocation visualized in 3D) irp.nih.gov

Chromosomal Translocations (Karyogram) Printed Napkin #chromosomal #translocations #karyogram #genetics #chromosomes #health #medicine #wordsandunwords

Chromosomal Translocations (Karyogram) Cloth Napkin

Chromosomal Translocations (Karyogram) Printed Napkin #chromosomal #translocations #karyogram #genetics #chromosomes #health #medicine #wordsandunwords

An unbalanced translocation occurs when a child inherits a chromosome with extra or missing genetic material from a parent with a balanced translocation.

An unbalanced translocation occurs when a child inherits a chromosome with extra or missing genetic material from a parent with a balanced translocation.

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