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Basement Membrane Antibodies. These antibodies are responsible for damaging the Glomerular Basement Membrane forcing it to cause damage to kidney. In some cases inspiration of hydrocarbon solvents while breathing and viral infections of respiratory system may also result in Goodpasture syndrome. This occurs when immune system of body mistakenly attacks tissues or organs assuming them to be foreign chemicals and viruses. Epidemiology of Goodpasture's Syndrome or Anti-GBM Disease…

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Goodpasture's is young male with HEMOPTYSIS and ARF with crescentic glomerulonephritis and Linear IgG staining or anti-GBM (Anti-GBM disease can be just kidney, but if it also cross reacts with alveoli in lungs, then it's called Goodpasture's syndrome. It is continuous/linear with IgG because the antibody is against col IV in the basement membrane.)

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Goodpasture Syndrome Instructional Tutorial Video QBanks for AMC Exams, MCCEE, MCCQE & USMLE URL:

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ASFA defines Category I indications as disorders for which apheresis is accepted as first-line therapy, either as a primary standalone treatment or in conjunction with other modes of treatment. Examples include thrombotic thrombocytopenic purpura (TTP), myasthenia gravis, and Goodpasture syndrome with diffuse alveolar hemorrhage.

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Ernest W. Goodpasture (October 17, 1886 – September 20, 1960) was an American pathologist and physician. Known for Goodpasture's syndrome.

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Management And Special Types Of Acute Nephritic Syndrome (Goodpasture’s Syndrome)

Complications arising during the course of the disease, such as hypertensive encephalopathy, cardiac failure with pulmonary edema, hyperkalemia and uremia demand active intervention.

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