Smoked Meatloaf Prep time 15 mins Cook time 3 hours Ingredients: Favorite 2 pound meatloaf recipe Start up your smoker and get it to 250F. You can use many different types of wood (hickory, pecan, maple, mesquite). I used hickory for this smoke. Place meatloaf in smoker once the smoker reaches 250F. Brush with favorite topping after about 2 hours of smoking. Remove when the internal temperature is at 160F.