August 28, 2013: Hutchinson-Gilford Progeria Syndrome is an extremely rare genetic disease wherein symptoms resembling aspects of aging are manifested at a very early age. The word progeria comes from the Greek words "pro" (πρό), meaning "before" or "premature", and "gēras" (γῆρας), meaning "old age". The disorder has a very low incident rate, occurring in an estimated 1 per 8 million live births.
This is a condition known as Hutchinson-Gilford Progeria Syndrome. It is a very rare condition that accelerates the aging process in children. The average life span for children with this disorder is 13 years of age.
Progeria (also known as “Hutchinson–Gilford progeria syndrome” and “Hutchinson–Gilford syndrome”) is an extremely rare, severe, genetic condition wherein symptoms resembling aspects of aging are manifested at an early age.
Hutchinson-Gilford Progeria Syndrome: This syndrome is caused by mutations in the LMNA gene that result in the production of an abnormal version of the lamin A protein. The altered protein makes the nuclear envelope unstable and progressively damages the nucleus, making cells more likely to die prematurely. The disease causes premature aging and severe hardening of the arteries beginning in childhood. This condition greatly increases the chances having a heart attack or stroke at a young…
"This weekend, in a heartbreaking phone call from his parents, I learned of the death of Sam Berns, a courageous young man with Hutchinson-Gilford Progeria Syndrome. Sam may have only lived 17 years, but in his short life he taught the rest of us a lot about how to live." - NIH Director Francis Collins on 1/12/2013. Photo of Collins with cookie monster and Sam Berns at TEDMED 2012