Hashimoto's Thyroiditis (HT) in Patients With Normal Thyroid-stimulating Hormone Levels--HT is one of the most common autoimmune endocrine disorders and often leads to hypothyroidism. It has been shown to substantially affect a patient's quality of life. Associated diseases are thought to promote hypothyroidism. Patients often suffer symptoms when thyroid tests are in the normal range. Independent of thyroid function, HT is linked associated with many other autoimmune disorders.
Takeda agreed to fork over $8 million initially to Resolve as the startup works toward the start of first human studies in 2013 for the lead compound, RSLV-132, a nuclease Fc fusion protein. The deal includes backup compounds as well. And if planned Phase 1b/2a work for the front runner goes as hoped, Takeda could use its exclusive option from the deal and take over global development and commercialization of the compound, leading to up to $247 million in development payments to Resolve.
"Trials to Address Efficacy of Midodrine 18 Years After It Gains FDA Approval" // I am really hoping that midodrine will be proven to be beneficial. It is a necessary treatment for many of us with low blood pressure. Removal of this drug from the market would be devastating.
Waldenstrom macroglobulinemia is chronic malignant lymphoproliferative disorder which is a type of non Hodgkin lymphoma. It is characterized by elevated blood viscosity due to increases immunoglobulin M (IgM) and bone marrow lymphocytic infiltrates