Tsunade (綱手, Tsunade) is one of Konohagakure's legendary Sannin. Though celebrated as the world's most powerful kunoichi and its greatest medical-nin, Tsunade abandoned the life of the ninja for many years in pursuit of other goals. She is eventually persuaded to return to Konoha and becomes its Fifth Hokage where her skills were invaluable to the village.
Tsunade Senju the Fifth Hokage, granddaughter of Hashirama and Mito, grandniece of Tobirama and older sister of her younger brother and former girlfriend of Dan, student of Hiruzen pupil of her granduncle the Second Hokage Tobirama Senju, teamate of Jiraiya and Orochimaru.
Gaara gambles against Lady Tsunade!! [Alternate Story] - YouTube