Researchers pinpoint brain region as ‘ground zero’ of Alzheimer’s disease. It's the "locus coeruleus", a small bluish part of the brainstem that releases norepinephrine, the neurotransmitter responsible for regulating heart rate, attention, memory and cognition.
Researchers pinpoint brain region as ‘ground zero’ of Alzheimer’s disease The locus coeruleus is a small part of the brainstem that releases the neurotransmitter responsible for regulating heart rate, attention, memory and cognition.
The chemoreceptor trigger zone (CTZ) is an area of the medulla that receives inputs from blood-borne drugs, and communicates with the vomiting center to initiate vomiting. The CTZ is close to the area postrema on the floor of the fourth ventricle & is outside of the BBB. The neurotransmitters implicated in the control of nausea and vomiting include ACh, DA, histamine (H-1R), substance P, and 5-HT. The BBB is not as developed here, and drugs such as DA may stimulate the CTZ. ORs control the…
Researchers Show How Lost Sleep Leads to Lost Neurons - NeuroscienceNews.com First report in preclincal study showing extended wakefulness can result in neuronal injury. Image shows a high magnification micrograph of the locus coeruleus. The locus coeruleus is a nucleus found in the rostral pons in the lateral floor of the fourth ventricle. Credit Nephron.
Ketamine blocks glutamate NMDA receptors in the brain. Increases brain-derived neurotrophic factor (BDNF, important for long-term memory and the creation of new synapses) and restores healthy mushroom-shaped spines on the dendrites of neurons in the prefrontal cortex. It may also affect the monoamines norepinephrine (NE) and dopamine. In rats, increased the firing rate of NE neurons in the locus coeruleus and also increased spontaneous firing dopamine cells in the ventral tegmental area.