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Alzheimer's Disease: New Study Reveals Locus Coeruleus As First Brain Structure Affected By Disease

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Scientists pinpoint exact area of the brain where Alzheimer's begins

A critical but vulnerable region in the brain, the locus coeruleus (pictured in blue), is subject to damage decades before symptoms of dementia appear, scientists have discovered

Ketamine blocks glutamate NMDA receptors in the brain. Increases brain-derived neurotrophic factor (BDNF, important for long-term memory and the creation of new synapses) and restores healthy mushroom-shaped spines on the dendrites of neurons in the prefrontal cortex. It may also affect the monoamines norepinephrine (NE) and dopamine. In rats, increased the firing rate of NE neurons in the locus coeruleus and also increased spontaneous firing dopamine cells in the ventral tegmental area.

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Researchers Show How Lost Sleep Leads to Lost Neurons - First report in preclincal study showing extended wakefulness can result in neuronal injury. Image shows a high magnification micrograph of the locus coeruleus. The locus coeruleus is a nucleus found in the rostral pons in the lateral floor of the fourth ventricle. Credit Nephron.

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‘Ground Zero’ Of Alzheimer’s: Locus Coeruleus Identified As Critical Starting…

Locus Coeruleus Painting by April Zanne Johnson

Saatchi Art Artist April Zanne Johnson; Painting, "Locus Coeruleus" #art