Nephron again. Proximal tube: Recapture of WATER, IONS and NUTRIENTS Descending loop of Henle: reabsorption of water. Ascending loop of Henel: permeable to ions Distal tubule: reabsorption of K+ and NaCl Collecting duct: to the renal pelvis we go

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Nephron (from Greek νεφρός - nephros, meaning "kidney") is the basic structural and functional unit of the kidney. Its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and…

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Loop diuretics are diuretics that act at the ascending loop of Henle in the kidney. They are primarily used in medicine to treat hypertension and edema often due to congestive heart failure or renal insufficiency.

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Diuretics - Site of Action in Renal Tubule PCT: mannitol, acetazolamide Loop of Henle: furosemide, bumetanide, torsemide, ethacrynic acid (for sulfa allergy) proximal DCT: thiazides (chlorothiazide) distal DCT: amiloride, triamterene (K-sparing); spironolactone collecting duct: ADH

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Furosemide aka Lasix most commonly used diuretic. Used to reduce body water content (usually by inducing urination) for 2 conditions: hypertension or edema. It's the #1 treatment for edema assoc c CHF (aka left-sided) also used for pts c cirrhosis or renal impairment. A loop-diuretic, it acts on the Loop of Henle in the kidney. As it's NOT a potassium-sparing diuretic, most common adverse effect is electrolyte imbalance. Monitor lab and I/O. Lasix "lasts 6 hours" referring to duration of…

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