Osage Orange Fruit (Maclura pomifera) The fruit has a pleasant and mild odor, but is inedible for the most part. Although it is not strongly poisonous, eating it may cause vomiting. However, the seeds of the fruit are edible. The fruit was once used to repel spiders by placing one under the bed. Various studies have found elemol, an extract of Osage orange, to repel several species of mosquitos, cockroaches, crickets, and ticks.