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Lead causes a Microcytic Anemia. Occupational exposures = batteries, plumbing, mining, painting, auto repair. Neurologic manifestations (hand clumsiness) + microcytic anemia. Treated with chelation therapy.

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Types of microcytic, hypochromic anemia... Iron deficiency will have a high RDW with low ferritin... Thalassemia's will have normal RDW and elevated ferritin (due to RBC turnover)... after thalassemia is suspected, electrophoresis should be done to distinguish alpha (normal) from beta (elevated HbA2 levels)

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Sideroblastic anemia. Presence of anemia + ringed sideroblasts. Hypochromic, BIMODAL RBC population. +/- Pappenheimer bodies (iron). Increased iron stores in BM. All iron studies are elevated (but distinguish from hemochromocytosis because SA has low hgb and low MCV). CAUSES: ACQUIRED = RARS, meds, alcohol, Pearson syndrome and low copper. VAST MAJORITY HAVE CLONAL DEFECT. MACROCYTIC. >15% RS. INHERITED = rare, X-linked. ALAS2 gene. MICROCYTIC. Can try giving a ton of B6.

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from NCLEX Quiz

Laboratory Values in Microcytic Anemias Cheat Sheet

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