Addison’s disease-- (also Addison disease, chronic adrenal insufficiency, hypocortisolism, and hypoadrenalism) is a rare, chronic endocrine system disorder in which the adrenal glands do not produce sufficient steroid hormones (glucocorticoids and mineralocorticoids). It is characterised by a number of relatively nonspecific symptoms, such as abdominal pain and weakness, but under certain circumstances, these may progress to Addisonian crisis, a severe illness which may include
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Fig. 1 The hypothalamic–pituitary–adrenal (HPA) axis, the negative feedback response of animals to an acute stressor compared with those under chronic stress, and the major impacts stressors have on bodily processes (boxes). Figure adapted from Boonstra et al. (1998)