NMDA receptor antagonists and depression | Abcam

NMDA receptor antagonists and depression | Abcam

There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, adolescent cynomolgus monkeys that were injected daily for six months with the non-competitive NMDA antagonist ketamine showed decreased locomotor activity and increased apoptosis of cells in their prefrontal cortices.

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate…

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate…

The similarity between NMDA receptor antagonist-induced psychosis and schizophrenia has led to the widespread use of the drugs to provide models to aid the development of novel treatments for the disorder.

The similarity between NMDA receptor antagonist-induced psychosis and schizophrenia has led to the widespread use of the drugs to provide models to aid the development of novel treatments for the disorder.

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

NMDA receptor antagonist ... Can be used to treat resistant forms of Catatonia

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Alomone Labs D-AP5, a competitive NMDA receptor antagonist.

Ketamine :  NMDA receptor antagonist that is usually used in anesthesia in humans and animals.  Often  delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is

Ketamine : NMDA receptor antagonist that is usually used in anesthesia in humans and animals. Often delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is

Biochemistry of Memantine:   The drug belongs to a class of drugs called NMDA receptor antagonists, which reduce certain types of brain activity by binding to NMDA receptors on brain cells and blocking the activity of the neurotransmitter glutamate. At normal levels, glutamate aids in memory and learning, but if levels are too high, glutamate appears to overstimulate nerve cells, killing them through excitotoxicity.

Biochemistry of Memantine: The drug belongs to a class of drugs called NMDA receptor antagonists, which reduce certain types of brain activity by binding to NMDA receptors on brain cells and blocking the activity of the neurotransmitter glutamate. At normal levels, glutamate aids in memory and learning, but if levels are too high, glutamate appears to overstimulate nerve cells, killing them through excitotoxicity.

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