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Opioids, including heroin and prescription pain medications attach to opioid receptors on nerve cells in the body and the brain to produce pleasurable effects and pain relief.

Solomon H. Snyder - Wikipedia, the free encyclopedia 1973 - Candace Pert and Solomon Snyder demonstrate opioid receptors in brain

The μOR bind enkephalins & beta-endorphin but has low affinity for dynorphins.The μOR exist presynaptically in the periaqueductal gray region, & in the superficial dorsal horn of the spinal cord (substantia gelatinosa of Rolando). μOR are also found in the intestinal tract & cause constipation. Activation of the μ receptor by morphine causes analgesia, sedation, slightly reduced blood pressure, itching, nausea, euphoria, decreased respiration, & miosis. Overdoses can cause circulatory…

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Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. (Neurochemical Research, November 2010)

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Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. (Neurochemical Research, November 2010)

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