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Obliterative bronchiolitis (narrowed lumen). In the setting of bone marrow transplantation the presence of obliterative bronchiolitis and foci of organizing bronchopneumonia is diagnostic of pulmonary involvement by chronic graft versus host disease (GVHD).

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from Lung Disease News

Lung Diseases Found to Be Primarily Linked to Defects in Stem Cells and Not to Inflammation as Previously Thought

Lung Diseases Found to Be Primarily Linked to Defects in Stem Cells and Not to Inflammation as Previously Thought Lung Disease News

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It is very important to differentiate between acute consolidation and chronic consolidation, because it will limit the differential diagnosis. In chronic disease we think of: Neoplasm with lobar or segmental post-obstructive pneumonia. Lung neoplasms like bronchoalveolar carcinoma and lymphoma. Chronic post-infection diseases like organizing pneumonia (OP) or chronic eosinophilic pneumonia, which both present with multiple peripheral consolidations. Sarcoidosis is the great mimicker and…

The characteristic features are a combination of patchy interstitial chronic inflammation, Bronchiolitis Obliterans Organizing Pneumonia (BOOP) and poorly formed interstitial granulomas. Taken together, these features are highly suggestive of extrinsic allergic alveolitis and should prompt clinical investigation of possible exposures in the environment. Avian antigens ("pigeon-breeders lung") and exposure to moldy grain ("farmer's lung") are but a few of the specific named variants of…

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