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Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning.  ©Laguna Design/Science Source

SP8395: Antibodies and their antigen

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning. ©Laguna Design/Science Source

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Imaging B cells   James ML Hoehne A Mayer AT Lechtenberg K Moreno M Gowrishankar G Ilovich O Natarajan A Johnson EM Nguyen J Quach L Han M Buckwalter M Chandra S Gambhir SS. Imaging B cells in a mouse model of multiple sclerosis using 64Cu-Rituximab-PET. J Nucl Med. 2017 Jul 7. pii: jnumed.117.189597. doi: 10.2967/jnumed.117.189597. [Epub ahead of print] B lymphocytes are a key pathological feature of multiple sclerosis (MS) and are becoming an important therapeutic target for this…

Imaging B cells James ML Hoehne A Mayer AT Lechtenberg K Moreno M Gowrishankar G Ilovich O Natarajan A Johnson EM Nguyen J Quach L Han M Buckwalter M Chandra S Gambhir SS. Imaging B cells in a mouse model of multiple sclerosis using 64Cu-Rituximab-PET. J Nucl Med. 2017 Jul 7. pii: jnumed.117.189597. doi: 10.2967/jnumed.117.189597. [Epub ahead of print] B lymphocytes are a key pathological feature of multiple sclerosis (MS) and are becoming an important therapeutic target for this…

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Multidrug ABC transporter, P-glycoprotein (with sound)

Multidrug ABC transporter, P-glycoprotein (with sound)

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological IssuesThis review of the scientific literature on sucralose (Splenda) is cause for concern. Some of the biological effects of sucralose include:~ alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,~ metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,~ induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal ...

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological IssuesThis review of the scientific literature on sucralose (Splenda) is cause for concern. Some of the biological effects of sucralose include:~ alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,~ metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,~ induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal ...

P-Glycoprotein

P-Glycoprotein

Piperine is an alkaloid extracted from black pepper (P. nigrum) and long pepper (P. longum). Previous studies have shown that piperine has anti-inflammatory, antiarthritic and anti-depressant effects [8] [9]. Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000% [11]. In a clinical study, simultaneous…

Piperine is an alkaloid extracted from black pepper (P. nigrum) and long pepper (P. longum). Previous studies have shown that piperine has anti-inflammatory, antiarthritic and anti-depressant effects [8] [9]. Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000% [11]. In a clinical study, simultaneous…

How Splenda makes you fat. Splenda reduces the amount of good bacteria in the intestines by 50%, increases the pH level in the intestines, contributes to increases in body weight and affects the P-glycoprotein (P-gp) in the body in such a way that crucial health-related drugs could be rejected"  How much Splenda caused this? It was the equivalent of 7 packets. Over time and daily use this could have extreme consequences’ on ones health and weight.

How Splenda makes you fat. Splenda reduces the amount of good bacteria in the intestines by 50%, increases the pH level in the intestines, contributes to increases in body weight and affects the P-glycoprotein (P-gp) in the body in such a way that crucial health-related drugs could be rejected" How much Splenda caused this? It was the equivalent of 7 packets. Over time and daily use this could have extreme consequences’ on ones health and weight.

Splenda alters gut microflora and increases intestinal p-glycoprotein and…

Splenda alters gut microflora and increases intestinal p-glycoprotein and…

Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

Simplified efflux mechanism of P-gp substrate

Simplified efflux mechanism of P-gp substrate

ABC Transporter Pgp-1 ( P-glycoprotein-1) - YouTube

ABC Transporter Pgp-1 ( P-glycoprotein-1) - YouTube

The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein.

The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein.