Thank God we now know what this syndrome is and those suffering from it don't have to live their lives in a circus.  Proteus syndrome--a rare genetic mutation.

Shrinking my 17stone legs: Hope for woman whose limbs wouldn't stop growing after doctors develop pioneering treatment

Fannie Mills, also known as "The Ohio Big Foot Girl." She suffered from a rare disorder known as "Milroy's Disease" which causes uncontrolled growth in the feet and legs.

John Merrick, aka "The Elephant Man," had a terrifying appearance accompanied by an utterly fascinating life.

Joseph Carey Merrick August 1862 – 11 April sometimes incorrectly referred to as John Merrick, was an English man with severe deformities who was exhibited as a human curiosity named the Elephant Man.

The skeleton of Joseph Carey Merrick - image Ray Crundwell, Queen Mary University of London

The skeleton of Joseph Carey Merrick the most famous sufferer of Proteus Syndrome. Also known as the elephant man- image Ray Crundwell, Queen Mary University of London

Proteus syndrome - The Elephant Man - John Merrick, as he was.

Proteus syndrome: The Elephant Man and beyond

Joseph Merrick photographed, c. Joseph Carey Merrick – sometimes incorrectly referred to as John Merrick, was an English man with severe deformities who was exhibited as a human curiosity named the Elephant Man.

Neurofibromatosis disease Variable expressivity means this disease may result in the extreme, or in almost no manifestation, even in siblings both with the disease.

74 year old woman with Von Recklinghausen's Disease, Neurofibromatosis type I and Breast Cancer

Molecular explanation of Proteus Syndrome.  Explanation: activating mutation in AKT1 in a percentage of cells.

SOLAMEN syndrome is caused by a mutation in the PTEN gene (Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus).

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