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Receptor Tyrosine Kinases (Hardcover)

Video Abstract: The Evolving Role of Maintenance Therapy Using Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR GKIs) in the Management of Advanced Non-Small Cell Lung Cancer

Quizartinib is an orally available small molecule with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis.

EGFR is a trans-membrane receptor belonging to the erbB/HER-family of RTK. EGFR exists on the cell surface and can be activated by EGF and TGF-alpha. Many important signaling cascades, like MAPK, Akt, and JNK pathways, could be the downstream of EGFR.

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The pattern for development of various types of blood cells in the bone marrow. (BFU-E—burst-forming unit-erythroid; CFU-GM—colony-forming unit-granulocyte-macrophage; CFU-mega—colony-forming unit-megakaryocyte; EPO—erythropoietin; EPOR—surface component of the erythropoietin receptor; FLT-3L—fms-like tyrosine kinase 3 ligand; G-CSF—granulocyte colony-stimulating factor; GM-CSF—granulocyte-macrophage colony-stimulating factor; IL— interleukin; M-CSF—macrophage colony-stimulating factor…

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