Roy Kelton Orbison began his career in the 1950's, becoming the biggest selling artist of the early 1960's. He suffered many tragedies in the late 1960's. When he decided to record again, it was one of the most anticipated comebacks in music history. "She's a Mystery to Me" is the single from Roy Orbison's 1989 album, 'Mystery Girl'. The track was written for Orbison by Bono and The Edge of U2. The album 'Mystery Girl' received its name from the song.