Substance P. Neuropeptide; neurotransmittor and -modulator. Composed of a chain of 11 amino acid residues. Substance P is released from the terminals of specific sensory nerves. It is found in the brain and spinal cord and is associated with inflammatory processes and pain.
What is Substance P & How Does it Cause Fibromyalgia Pain?
Research suggests that some people with fibromyalgia may have elevated levels of substance P. This is believed to be one of several abnormalities in the nervous system that work together to increase pain sensitivity in the condition, a process that's often referred to as "turning up the volume" on pain. Substance P often functions as a neurotransmitter, which means that it communicates signals from one brain cell to another.
Extraordinary Homemade Hot Pepper Cream for Arthritis & Joint Pain. For all we know, the hot pepper contains capsaicin that reduces the amount of substance P. The substance P is a brain chemical that carries pain signals. So with less of it, you feel less pain.