Myelin Autoimmunity in T cells. Time to say schtop!. MS lesions are EBV killing zones   van Nierop GP van Luijn MM Michels SS Melief MJ Janssen M Langerak AW Ouwendijk WJD Hintzen RQ Verjans GMGM.Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients.Acta Neuropathol. 2017 doi: 10.1007/s00401-017-1744-4. [Epub ahead of print] T cells are considered pivotal in the pathology of multiple sclerosis (MS) but their function and antigen…

Myelin Autoimmunity in T cells. Time to say schtop!. MS lesions are EBV killing zones van Nierop GP van Luijn MM Michels SS Melief MJ Janssen M Langerak AW Ouwendijk WJD Hintzen RQ Verjans GMGM.Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients.Acta Neuropathol. 2017 doi: 10.1007/s00401-017-1744-4. [Epub ahead of print] T cells are considered pivotal in the pathology of multiple sclerosis (MS) but their function and antigen…

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

Differences Between B-Cells and T-Cells. T cells and B cells are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity.

Differences Between B-Cells and T-Cells. T cells and B cells are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity.

This detail description of the phases of mitosis for the students to see from the beginning to the end.

This detail description of the phases of mitosis for the students to see from the beginning to the end.

Novartis on Wednesday touted new data from its T-cell therapy CTL019, saying it is on a par with results of experimental molecules from Kite Pharma and Juno Therapeutics that also target aggressive blood cancers.

Novartis touts new T-cell therapy data in race for FDA approval

Novartis on Wednesday touted new data from its T-cell therapy CTL019, saying it is on a par with results of experimental molecules from Kite Pharma and Juno Therapeutics that also target aggressive blood cancers.

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How does Cladribine Work. It kills B cells   David BakerSamuel S. HerrodCesar Alvarez-GonzalezLukasz ZalewskiChristo Albor and Klaus Schmierer. Both cladribine and alemtuzumab may effect MS via B-cell depletion  Neurology Neuroimmunology Neurosurgery. http://dx.doi.org/10.1212/NXI.0000000000000360Objective: To understand the efficacy of cladribine (CLAD) treatment in MS through analysis of lymphocyte subsets collected but not reported in the pivotal phase III trials of cladribine and…

How does Cladribine Work. It kills B cells David BakerSamuel S. HerrodCesar Alvarez-GonzalezLukasz ZalewskiChristo Albor and Klaus Schmierer. Both cladribine and alemtuzumab may effect MS via B-cell depletion Neurology Neuroimmunology Neurosurgery. http://dx.doi.org/10.1212/NXI.0000000000000360Objective: To understand the efficacy of cladribine (CLAD) treatment in MS through analysis of lymphocyte subsets collected but not reported in the pivotal phase III trials of cladribine and…

Regulatory T cells (Tregs; pronounced 'tee-regs'), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth, researchers have discovered. Without these immune cells as partners, the researchers found, the stem cells cannot regenerate hair follicles, leading to baldness.

New hair growth mechanism discovered: Faulty immune cells may play role in alopecia, other forms of baldness

Regulatory T cells (Tregs; pronounced 'tee-regs'), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth, researchers have discovered. Without these immune cells as partners, the researchers found, the stem cells cannot regenerate hair follicles, leading to baldness.

New approach in T-cell therapy to treat cancer [Cancer Research 2018]. It consists in fusing together the inhibitory surface receptor PD-1 with activating cytoplasmic domain of CD28 (PD-1:28). This results in much higher proliferation and cytotoxic activity of T cells in tumor mileu. This treatment affects only avidity but not affinity of T cells, thus, making them less likely to cause autoimmunity and toxicity. This modification is compatible with adoptive T cell transfer.

New approach in T-cell therapy to treat cancer

New approach in T-cell therapy to treat cancer [Cancer Research 2018]. It consists in fusing together the inhibitory surface receptor PD-1 with activating cytoplasmic domain of CD28 (PD-1:28). This results in much higher proliferation and cytotoxic activity of T cells in tumor mileu. This treatment affects only avidity but not affinity of T cells, thus, making them less likely to cause autoimmunity and toxicity. This modification is compatible with adoptive T cell transfer.

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