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A leaky what? Simply put, abnormal intestinal permeability (aka Leaky Gut) arises when the tight junctions between these cells loosen, allowing for large, immune-confounding particles to be absorbed into the bloodstream. These can wreak havoc on many of the body’s tissues, including the liver, the thyroid, the skin, the joints, and the brain itself. #seasonalcleanse #farmacopia

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Role of flavonoids in intestinal tight junction regulation - Journal of Nutritional Biochemistry (Quercetin enhances intestinal tight junction barrier function.)

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Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor sign...

Adherens and tight junctions: Structure, function and connections to the actin cytoskeletonFull-size image (10 K)

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Zonulin's Role In Your Leaky Gut -What is Zonulin? Zonulin is a protein .. that opens the normally closed spaces between cells of the intestinal lining … (these) .. garage doors .. allow transfer of nutrients and other molecules from the intestine into the body when they are open … zonulin acts as the garage door opener ... When these tight junctions are left open, molecules that shouldn’t be absorbed are exposed to the blood which can cause the body’s immune system to react.

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Germinal epithelium of the testicle. 1: basal lamina 2: spermatogonia 3: spermatocyte 1st order 4: spermatocyte 2nd order 5: spermatid 6: mature spermatid 7: Sertoli cell 8: tight junction (blood testis barrier)

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Leaky Gut is Benchmark of Autoimmunity. Study: “Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease.” 7 food additives: These additives are; sugar, salt, emulsifiers, organic solvents, gluten, microbial transglutaminase, and nanoparticles.

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Figure 1. AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

ARTICLE: Is a 300% increase in Crohn’s disease the result of our escalating exposure to wireless technologies? RF energy vibrates at the cellular level causing leakage in the Blood-Brain Barrier and intestines. Microwave ovens operate at a 2.45 GHz frequency which excite water molecules. WiFi/Bluetooth operate at the same. Endothelial cells are connected by tight junctions sensitive to RF microwave energy. https://faculty.washington.edu/chudler/bbb.html

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Protection against Gluten-mediated Tight Junction Injury with a Novel Li...

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Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

"Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Diabetes Paradigms," from the Annals of the New York Academy of Sciences

Research and leaders in the field of Hashimoto’s theorize that gluten is on many occasions part of the original causes of Hashimoto’s due to its molecular similarity with the Thyroid gland. Once the gluten molecules enter through the tight junctions in the gut and trigger an immune reaction, the immune system then looks through-out the body for other possible molecules which are similar – one of which is the Thyroid gland.

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10 Foods That Are Wreaking Havoc on Your Gut

If you suffer from chronic tummy issues, you want to consider limiting foods that contain gluten. Kellman explains that gluten—a form of protein found in wheat, barley, rye, and other grains—can trigger the production of zonulin, a biochemical that opens up the tight junctions of your intestinal wall. “When you eat gluten in moderate amounts—for example, a twice-weekly serving of toast or pasta—your body has a chance to tighten up those junctions and maintain intestinal health,” he says. ...