Y: The Last Man (series) | Brian Vaughn, Pia Guerra, J.G. Jones -- A 60-issue comic book series (collected in 10 paperback volumes or 5 hardcover collections) that depicts a dystopian future where some event has instantly wiped out every mammal with a Y chromosome on Earth and civilization's struggle to survive from the shock. Stellar long-form work!
Yorick Brown is the only male human left alive after a mysterious plague kills all Y-chromosome carriers on earth but somehow this does not make him more desirable. Sometimes a guy just can't catch a break.