Margaret of Anjou (1430 –1482) - wife of Henry VI; a key figure in the Wars of the Roses & at times personally led the Lancastrians. She lost her son Edward, Prince of Wales, at the Battle of Tewkesbury.
Juana of Castile with her eldest children: Eleanor of Habsburg, Queen of Portugal and France, and Charles V, King of Spain and Holy Roman Emperor. Her sister was Catherine of Aragon who became Queen of England when she married Henry VIII.
Henry Frederick, Prince of Wales (19 February 1594 – 6 November 1612) was the eldest son of King James I & VI and Anne of Denmark. His name comes from grandfathers Henry Stuart, Lord Darnley and Frederick II of Denmark. Prince Henry was widely seen as a bright and promising heir to his father's throne. However, at the age of 18, he predeceased his father when he died of typhoid fever. Subsequently, the heirship to the English and Scottish thrones passed to his younger brother Charles.