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Here, a team led by researchers at the University of Utah School of Medicine show that transposable elements, through their capacity to move and spread in genomes in a lineage-specific fashion, as well as their ability to introduce regulatory sequences upon chromosomal insertion, represent a major force shaping the lncRNA repertoire of humans, mice, and zebrafish. Not only do TEs make up a substantial fraction of mature lncRNA transcripts, they are also enriched in the vicinity of lncRNA…

Kcnq1ot1 is a long noncoding ribonucleic acid (RNA; lncRNA) that participates in the regulation of genes within the Kcnq1 imprinting domain....

There is little insight into whether and how lncRNAs effect human vascular cell phenotypes. Now, researchers at the University of Rochester...

Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. Researchers at the Ecole Polytech...

Researchers at the Mizuho Information & Research Institute designed a novel estimator for multiple alignments of structured RNAs, based on maximizing the expected accuracy of predictions. First, they define the maximum expected accuracy (MEA) estimator for pairwise alignment of RNA sequences. This maximizes the expected sum-of-pairs score (SPS) of a predicted alignment under a probability distribution of alignments given by marginalizing the Sankoff model. Then, by approximating the MEA…

The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. How...

Recent large-scale transcriptome analyses have revealed that the human genome contains more than just protein-coding genes. Indeed, a large ...

starBase v2.0 for decoding miRNA-mRNA, miRNA-ceRNA, miRNA-lncRNA, miRNA-circRNA, miRNA-pseudogene and protein-RNA interaction networks from ...

Staufen1-mediated mRNA decay (SMD) degrades mRNAs that harbor a Staufen1-binding site (SBS) in their 3′ untranslated regions (UTRs). Human SBSs can form by intermolecular base-pairing between a 3′ UTR Alu element and an Alu element within a long noncoding RNA (lncRNA) called a ½-sbsRNA. Since Alu elements are confined to primates, it was unclear how SMD occurs in rodents. Here, researchers at the University of Rochester identify mouse mRNA 3′ UTRs and lncRNAs that contain a B1, B2, B4,

The study of long noncoding RNAs (lncRNAs) is still in its infancy with more putative RNAs identified than those with ascribed functions. De...