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Here, a team led by researchers at the University of Utah School of Medicine show that transposable elements, through their capacity to move and spread in genomes in a lineage-specific fashion, as well as their ability to introduce regulatory sequences upon chromosomal insertion, represent a major force shaping the lncRNA repertoire of humans, mice, and zebrafish. Not only do TEs make up a substantial fraction of mature lncRNA transcripts, they are also enriched in the vicinity of lncRNA…

Local regulation of gene expression by lncRNA promoters, transcription and splicing #biochemistry #biology #by-product #Gene #geneexpression #GeneExpression #genetics #genotype #Health_Medical_Pharma #herpes #hypersensitivity #Ihypersensitivity #inter-libraryloanservices #Longnon-codingRNA #measurementprotocol #measurementprotocol #MolecularBiology #onlineaccess #PDF #recombination...

The mammalian genome harbors thousands of long noncoding RNA (lncRNA) genes. Recent studies have indicated the involvement of several of the...

LncRNA2Function – a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data - The GENCODE project has collected over 10,000 human long non-coding RNA (lncRNA) genes. However, the vast majority of them remain to be functionally characterized. Computational investigation of potential functions of human lncRNA genes is helpful to guide further experimental studies on lncRNAs...

Researchers at the University of Regensburg, Germany recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes mutated in human skin diseases characterized by disrupted epidermal barrier formation. High-throughput analyses of TINCR RNA- and protein-interactomes revealed TINCR interaction with differentiation mRNAs as well as the Staufen1 protein. TINCR, together with Staufen1, seems to stabilize a subset of mRNAs required for…

Co-LncRNA – investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data Long non-coding RNAs (lncRNAs) are emerging as key regulators of diverse biological processes and diseases. However, the combinatorial effects of these molecules in a specific biological function are poorly understood. Identifying co-expressed protein-coding genes of lncRNAs would provide ample insight into lncRNA functions...

Researchers at SAIC-Frederick report here the presence of an intron 2 promoter in several KIR genes that produce a spliced antisense transcript. This long noncoding RNA (lncRNA) transcript contains antisense sequence complementary to KIR-coding exons 1 and 2 as well as the proximal promoter region of the KIR genes.

lncRNA Blog - This year’s Science Breakthroughs of the Year include a remarkable new method to prepare single strands of ancient DNA and view their genomes, transcription activator–like effector nucleases that can destroy or alter specific genes, neutrino physics, the Encyclopedia of DNA Elements, the flawless performance of the Mars Curiosity rover, the first time an x-ray laser was used to determine the structure of a protein, the use of a brain-machine interface by paralyzed human…

A substantial proportion of lncRNAs reside within, or are dynamically shuttled, to the cytoplasm where they regulate protein localization, mRNA translation and stability. For example, the NFAT transcription factor is trafficked from the cytoplasm to the nucleus to activate target genes in response to calcium-dependent signals. A lncRNA, NRON, complexes with importin-β proteins and regulates the trafficking of NFAT113. Notably, NRON inhibits the trafficking of NFAT to the nucleus…