Here, a team led by researchers at the University of Utah School of Medicine show that transposable elements, through their capacity to move and spread in genomes in a lineage-specific fashion, as well as their ability to introduce regulatory sequences upon chromosomal insertion, represent a major force shaping the lncRNA repertoire of humans, mice, and zebrafish. Not only do TEs make up a substantial fraction of mature lncRNA transcripts, they are also enriched in the vicinity of lncRNA…

Here, a team led by researchers at the University of Utah School of Medicine show that transposable elements, through their capacity to move and spread in genomes in a lineage-specific fashion, as well as their ability to introduce regulatory sequences upon chromosomal insertion, represent a major force shaping the lncRNA repertoire of humans, mice, and zebrafish. Not only do TEs make up a substantial fraction of mature lncRNA transcripts, they are also enriched in the vicinity of lncRNA…

Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here researchers at the Stanford University School of Medicine discover and characterize the sets of mouse lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including 54 pseudogene lncRNAs, several of which show exquisitely selective expression in response to specific cytokines and microbial…

Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here researchers at the Stanford University School of Medicine discover and characterize the sets of mouse lncRNAs induced by inflammatory signaling via TNFα. TNFα regulates hundreds of lncRNAs, including 54 pseudogene lncRNAs, several of which show exquisitely selective expression in response to specific cytokines and microbial…

With the development of whole genome and transcriptome sequencing technologies, long noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that lncRNAs act not only as the intermediary between DNA and protein but also as important protagonists of cellular functions. LncRNAs can regulate gene expression in many ways, including chromosome remodeling, transcription and post-transcriptional processing. Moreover, the dysregulation of lncRNAs has ...

With the development of whole genome and transcriptome sequencing technologies, long noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that lncRNAs act not only as the intermediary between DNA and protein but also as important protagonists of cellular functions. LncRNAs can regulate gene expression in many ways, including chromosome remodeling, transcription and post-transcriptional processing. Moreover, the dysregulation of lncRNAs has ...

TINCR - Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here, a team led by researchers at Stanford University School of Medicine show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mechanism.

TINCR - Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here, a team led by researchers at Stanford University School of Medicine show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mechanism.

A team led by researchers at Yale University School of Medicine demonstrate that H19 modulates let-7 availability by acting as a molecular s...

A team led by researchers at Yale University School of Medicine demonstrate that H19 modulates let-7 availability by acting as a molecular s...

In this study, researchers at the Shanghai Jiao Tong University School of Medicine, China found that lncRNA gastric carcinoma high expressed...

In this study, researchers at the Shanghai Jiao Tong University School of Medicine, China found that lncRNA gastric carcinoma high expressed...

A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated.    PTENpg1, a PTEN pseudogene, regulates PTEN via both sense and antisense RNAs, and there’s a histone modification in the mix, too.    PTEN gets silenced in lots of cancers. The team from Sweden, the U.S., and Australia…

A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated. PTENpg1, a PTEN pseudogene, regulates PTEN via both sense and antisense RNAs, and there’s a histone modification in the mix, too. PTEN gets silenced in lots of cancers. The team from Sweden, the U.S., and Australia…

Volume 56, Issue 10, October 2013 In this issue (15 articles)      EditorialNon-coding RNA annotation: Deciphering the second genetic cod...

Volume 56, Issue 10, October 2013 In this issue (15 articles) EditorialNon-coding RNA annotation: Deciphering the second genetic cod...

Researchers from the University of Massachusetts Medical School identify a long noncoding RNA that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2 mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on...

Researchers from the University of Massachusetts Medical School identify a long noncoding RNA that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2 mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on...

Pinterest
Search