Here, a team led by researchers at the University of Utah School of Medicine show that transposable elements, through their capacity to move and spread in genomes in a lineage-specific fashion, as well as their ability to introduce regulatory sequences upon chromosomal insertion, represent a major force shaping the lncRNA repertoire of humans, mice, and zebrafish. Not only do TEs make up a substantial fraction of mature lncRNA transcripts, they are also enriched in the vicinity of lncRNA…

Here, a team led by researchers at the University of Utah School of Medicine show that transposable elements, through their capacity to move and spread in genomes in a lineage-specific fashion, as well as their ability to introduce regulatory sequences upon chromosomal insertion, represent a major force shaping the lncRNA repertoire of humans, mice, and zebrafish. Not only do TEs make up a substantial fraction of mature lncRNA transcripts, they are also enriched in the vicinity of lncRNA…

Here a team led by researchers at Harvard Medical School generated high-resolution maps of Xist binding on the X chromosome across a develop...

Here a team led by researchers at Harvard Medical School generated high-resolution maps of Xist binding on the X chromosome across a develop...

In this study, researchers at the Jiangxi Maternal and Child Health Hospital, China described the lncRNA profiles in six preeclampsia placen...

In this study, researchers at the Jiangxi Maternal and Child Health Hospital, China described the lncRNA profiles in six preeclampsia placen...

A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated.    PTENpg1, a PTEN pseudogene, regulates PTEN via both sense and antisense RNAs, and there’s a histone modification in the mix, too.    PTEN gets silenced in lots of cancers. The team from Sweden, the U.S., and Australia…

A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated. PTENpg1, a PTEN pseudogene, regulates PTEN via both sense and antisense RNAs, and there’s a histone modification in the mix, too. PTEN gets silenced in lots of cancers. The team from Sweden, the U.S., and Australia…

In this study, a team led by researchers from Southern Illinois University School of Medicine show that loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo. Through deletion analysis, they identify an active region responsible for tumor cell growth inhibition within exon 4, which harbors two miR-211 binding sites. Importantly, this loc285194-mediated growth inhibition is in part due to specific suppression of miR-211…

In this study, a team led by researchers from Southern Illinois University School of Medicine show that loc285194 is a p53 transcription target; ectopic expression of loc285194 inhibits tumor cell growth both in vitro and in vivo. Through deletion analysis, they identify an active region responsible for tumor cell growth inhibition within exon 4, which harbors two miR-211 binding sites. Importantly, this loc285194-mediated growth inhibition is in part due to specific suppression of miR-211…

Volume 56, Issue 10, October 2013 In this issue (15 articles)      EditorialNon-coding RNA annotation: Deciphering the second genetic cod...

Volume 56, Issue 10, October 2013 In this issue (15 articles) EditorialNon-coding RNA annotation: Deciphering the second genetic cod...

The human brain is one of the most complex biological systems, and the cognitive abilities have greatly expanded compared to invertebrates w...

The human brain is one of the most complex biological systems, and the cognitive abilities have greatly expanded compared to invertebrates w...

In this review, the authors posit that a significant fraction of the genetic aetiology of cancer is exacted by noncoding regulatory sequences, particularly by long noncoding RNAs (lncRNAs). Recent studies indicate that several cancer risk loci are transcribed into lncRNAs and these transcripts play key roles in tumorigenesis. They discuss the epigenetic and other mechanisms through which lncRNAs function and how they contribute to each stage of cancer progression, understanding of which will…

In this review, the authors posit that a significant fraction of the genetic aetiology of cancer is exacted by noncoding regulatory sequences, particularly by long noncoding RNAs (lncRNAs). Recent studies indicate that several cancer risk loci are transcribed into lncRNAs and these transcripts play key roles in tumorigenesis. They discuss the epigenetic and other mechanisms through which lncRNAs function and how they contribute to each stage of cancer progression, understanding of which will…

A new class of transcripts, long non-coding RNAs (lncRNAs), has been recently found to be pervasively transcribed in the genome. These mRNA-like molecules, which lack significant protein-coding capacity, once thought to be a part of the dark matter, now have been implicated in a wide range of biological functions through diverse and as yet poorly understood molecular mechanisms. Multiple facets of evidence increasingly link mutations and dysregulations of lncRNAs to prostate cancer (PCA)…

A new class of transcripts, long non-coding RNAs (lncRNAs), has been recently found to be pervasively transcribed in the genome. These mRNA-like molecules, which lack significant protein-coding capacity, once thought to be a part of the dark matter, now have been implicated in a wide range of biological functions through diverse and as yet poorly understood molecular mechanisms. Multiple facets of evidence increasingly link mutations and dysregulations of lncRNAs to prostate cancer (PCA)…

Pluripotent stem cells, such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), represent useful systems for modeling normal development and human diseases, as well as promising tools for regenerative medicine. To fully explore their potential, however, a deep understanding of the molecular basis of stemness is crucial. In recent years, increasing evidence of the importance of regulation by ncRNAs in pluripotent cells is accumulating....

Pluripotent stem cells, such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), represent useful systems for modeling normal development and human diseases, as well as promising tools for regenerative medicine. To fully explore their potential, however, a deep understanding of the molecular basis of stemness is crucial. In recent years, increasing evidence of the importance of regulation by ncRNAs in pluripotent cells is accumulating....

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