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Apocynum cannabinum grows up to 2 meters/6 feet tall. The stems are reddish and contain a milky latex capable of causing skin blisters. The leaves are opposite, simple broad lanceolate, 7–15 cm long and 3–5 cm broad, entire, and smooth on top with white hairs on the underside. The flowers are produced in mid summer, with large sepals, and a five-lobed white corolla.